ea0041gp127 | Neuroendocrinology | ECE2016
Avendano Ma Soledad
, Ruiz-Pino Francisco
, Vazquez Ma Jesus
, Velasco Inmaculada
, Heras Violeta
, Torres Encarni
, Manuel Castellano Juan
, Roa Juan
, Pinilla Leonor
, Tena-Sempere Manuel
The G protein-coupled receptor (GPCR) kinase 2, GRK2, is a ubiquitous serine/threonine protein kinase that is able to phosphorylate and desensitize the active form of several GPCR. Compelling, as yet limited, evidence from in vitro studies have suggested a potential role of GRK2 in mediating desensitization of Gpr54, the canonical receptor for kisspeptins that is abundantly expressed in GnRH neurons. Yet, although kisspeptins have been universally recognized as essent...